PRF Applications in Endodontics. Mahmoud Torabinejad

      ©2020 Quintessence Publishing Co, Inc

      Quintessence Publishing Co, Inc

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      Batavia, IL 60510

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      Editor: Marieke Zaffron

      Editorial Assistant: Samantha Smith

      Design: Sue Zubek

      Production: Sue Robinson

      I dedicate this book to my wife, Parvin, and my children, Sara and Ali, with love.

      –MS

      I would like to thank my mentors, Dr Ronald J. Nicholson and Dr Chutima Mangkornkarn for inspiring me to become a better clinician and person, and to Dr Calvin Tae Nam for sharing his knowledge about PRF.

      –ESL

      To the soul of my dear father whom we lost to cancer early in his and our lives.

      –MT

      Contents

Foreword by Richard J. Miron

Preface

Contributors

Introduction by Mahmoud Torabinejad

1 Stem Cells in Regenerative Medicine

       C. Cameron Taylor | Habib Torfi | Mohammad Sabeti

       2 History, Science, Armamentarium, and How to Make PRF

       Edward S. Lee

       3 Nonsurgical Application: PRF for Regeneration Endodontics

       Mohammad Sabeti | Edward S. Lee

       4 Soft Tissue Applications

       Kayvon Javid | Gregori M. Kurtzman | Carlos Fernando Mourão

       5 Hard Tissue Applications

       Kayvon Javid | Gregori M. Kurtzman | Carlos Fernando Mourão

       6 PRF in Endodontic Surgery

       Mohammad Sabeti | Gregori M. Kurtzman Edward S. Lee | Eric Wong

       7 PRF for Socket Preservation

       Yogalakshmi Rajendran | Yvonne Kapila

       Index

Foreword

      The use of platelet-rich fibrin (PRF) has seen a rapid increase over the past decade, owing to its ability to rapidly release autologous growth factors harvested quite easily from peripheral blood. While original case studies dating back nearly two decades focused primarily on its use in medicine for the treatment of hard-to-heal wound ulcers, it is now well known that its inclusion of high concentrations of platelets and leukocytes has served several benefits in dentistry. Specifically, platelets are largely responsible for the release of various regenerative growth factors favoring wound healing, whereas leukocytes (white blood cells) participate in host defense against incoming pathogens. The ability to concentrate both cell types found within PRF has shown pronounced benefits in the oral cavity, an area particularly concentrated with various oral bacteria.

      Over the years, several research articles focused on the use of PRF for multiple applications in regenerative dentistry; more recently, publications have begun to emerge dealing specifically with its use in endodontics. I have the great pleasure to announce the launch of this new book, PRF Applications in Endodontics, which addresses this topic in extensive detail.

      The book begins by providing background knowledge on various cell types found in regenerative medicine with particular focus on stem cells. Thereafter, the book rapidly enters into a variety of chapters dedicated to PRF with a brief history regarding its scientific background, including growth factors, armamentarium, and protocols utilized to fabricate PRF. The discussion then transitions to nonsurgical applications in regenerative endodontics, as well as its use in dentistry, particularly for the formation of a bone grafting material complex including bone grafting particles and autologous PRF (aka “sticky bone”). Its use as an alternative to bone grafts and other biomaterials is further discussed in later chapters dealing with endodontic surgery. These include various endodontic procedures indicated following common human “accidents” (accidental tooth loss and replantation, for instance), for improvements in