The State of Science. Marc Zimmer

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      Copyright © 2020 by Marc Zimmer

      All rights reserved. No part of this book may be reproduced in any form or by any electronic or mechanical means, including information storage and retrieval systems, without written permission from the publisher, except by a reviewer who may quote passages in a review.

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      Name: Zimmer, Marc, author.

      Title: The state of science : what the future holds and the scientists making it happen / Marc Zimmer.

      Description: Guilford, Connecticut : Prometheus Books, [2020] | Includes bibliographical references. | Summary: “New research and innovations in the field of science are leading to life-changing and world-altering discoveries like never before. What does the horizon of science look like? Who are the scientists that are making it happen? And, how are we to introduce these revolutions to a society in which a segment of the population has become more and more skeptical of science? Climate change is the biggest challenge facing our nation, and scientists are working on renewable energy sources, meat alternatives, and carbon dioxide sequestration. At the same time, climate change deniers and the politicization of funding threaten their work. CRISPR (clustered regularly interspaced short palindromic repeats) repurposes bacterial defense systems to edit genes, which can change the way we live but also presents real ethical problems. Optogenetics will help neuroscientists map complicated neural circuitry deep inside the brain, shedding light on treating Alzheimer’s and Parkinson’s disease. Zimmer also investigates phony science ranging from questionable ‘health’ products to the fervent anti-vaccination movement. Zimmer introduces readers to the real people making these breakthroughs. Concluding with chapters on the rise of women in STEM fields, the importance of U.S. immigration policies to science, and new, unorthodox ways of DIY science and crowdsource funding, The State of Science shows where science is, where it is heading, and the scientists who are at the forefront of progress”—Provided by publisher.

      Identifiers: LCCN 2019054457 (print) | LCCN 2019054458 (ebook) | ISBN 9781633886391 (cloth) | ISBN 9781633886407 (epub)

      Subjects: LCSH: Science—History. | Science—Social aspects. | Science—Forecasting.

      Classification: LCC Q172 .Z56 2020 (print) | LCC Q172 (ebook) | DDC 500—dc23

      LC record available at https://lccn.loc.gov/2019054457

      LC ebook record available at https://lccn.loc.gov/2019054458

      Part One

      Science

      Chapter 1

      The Big Picture

      State of the Union address: A yearly speech given by the U.S. president to Congress and the people to tell them about important things that are affecting the country.—Merriam-Webster Collegiate Dictionary

      Every year the leaders of countries, corporations, and universities present their views of the current conditions of their respective institutions. Given the function of these statements, they are often a top-down view with a biased perspective designed to make their current administrations look good.

      There is no such annual report on science. This book is a report on the state of science from a practicing scientist, a view from the trenches. It is not meant to be a top-down view, nor is it meant to make anyone look good or bad.

      I have written this book because science is not the same as it was in the first 20–25 years of my career. The way science is done, funded, and disseminated is evolving. At the same time, science is being politicized, and the public’s trust in science is being undermined. Yet science remains the engine of our economy and is responsible for our improved well-being. And perhaps now more than ever before, it is at the cusp of altering the most fundamental aspects of our daily lives.

      What Is Science?

      This is probably a good point in the book to define “science” and “scientist.” The Merriam-Webster Collegiate Dictionary defines science as “the state of knowing” as distinguished from ignorance or misunderstanding.” However, I much prefer Karl Popper’s perspective, according to which a hypothesis has to be inherently disprovable for it to be a scientific theory. It is difficult to imagine an experiment that can disprove the existence of beauty and God. Hence the study of beauty and God is not science. Albert Einstein proposed the existence of gravitational waves. Their existence was provable, although the equipment to do so didn’t exist when Einstein came up with his general theory of relativity, and it took close to 100 years to actually prove that they exist (chapter 6). It was disprovable and therefore a scientific theory. Scientists use experiments to test their theories and hypotheses. No map shows the way to prove or disprove a theory; the scientific process is not linear. Neil Gershenfeld, director of MIT’s Center for Bits and Atoms, writes that “to find something that’s not already on the map, you need to leave the road and wander in the woods besides it.” He feels that nonscientists do not recognize that “science appears to be goal-directed only after the fact. While it’s unfolding, it is more like a chaotic dance of improvisation, than a victory march.”^[1] It is also important to realize that uncertainty is an inherent and unremovable component of scientific experimentation. It is not a weakness; it is a strength. Critics of science often disparage scientific results on the basis of included uncertainties. This is a mistake born from a lack of understanding.

      Before 1833, people who conducted experiments—who mixed, observed, and synthesized chemicals—were called natural philosophers. Newton, Galen, Galileo, and Mendel were all natural philosophers. In 1833 William Whewell, a professor at Cambridge University, coined the term “scientist” to highlight the fact that these were empirical folks and not philosophers of ideas. Like an artist works with art, a scientist works with science. As an analogy of “artist,” the word “scientist” was infused by Whewell with creativity, intuition, and professionalism.

      There is a commonly told tale that Whewell derived and popularized the term “scientist” because he needed an alternative to the commonly used phrase “man of science” to describe Mary Somerville in a positive review he was writing about her.^[2] If true this would be a great story, and Mary Somerville was worthy of the honor. Her book On the Connexion of the Physical Sciences was instrumental in making modern physics into a discipline and was frequently revised and republished, with nine separate editions. In 1879, the first women’s college at Oxford University was named in her honor. A main-belt asteroid (5771 Somerville) and a lunar crater in the eastern part of the moon are also named after her, and she graces all Scottish ten-pound notes printed from October 2018 onward. However, according to James Secord, professor of philosophy of science at the University of Cambridge, “Nowhere did Whewell or anyone else in