Clinical Pancreatology for Practising Gastroenterologists and Surgeons. Группа авторов
Demographics Etiology Diagnostic Work‐up Natural History and Risk of Progression Preventing Recurrences and Disease Progression Conclusion Acknowledgment References 21 Diagnosis and Therapeutic Approach to Pancreatic Exocrine Insufficiency after Acute Pancreatitis Introduction Symptoms Diagnosis Management Summary References 22 Asymptomatic Chronic Elevation of Serum Pancreatic Enzymes Introduction Physiology of Pancreatic Enzymes Pancreatic Abnormalities in Patients with Pancreatic Hyperenzymemia Gastrointestinal Diseases and Pancreatic Hyperenzymemia Macroenzymemia Systemic Conditions Associated with Hyperenzymemia Drug‐induced Hyperenzymemia Extrapancreatic Abnormalities in Patients with Hyperenzymemia Benign Pancreatic Hyperenzymemia (Gullo Syndrome) Algorithm for Management of CAPH (Figure 22.2) Conclusions References
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Section II: Chronic Pancreatitis
23 Definition and Etiology of Chronic Pancreatitis
Definition of Key Terms and Concepts
Traditional Definitions of Chronic Pancreatitis
Mechanistic Definition of Chronic Pancreatitis
Progressive Model of CP
Risk Factors and Etiologies
Subtypes of Inflammatory Diseases of the Pancreas
References
24 Epidemiology of Chronic Pancreatitis
Why is Chronic Pancreatitis Epidemiology so Imprecise?
Epidemiology
Why are Reported Data on Incidence and Prevalence of Chronic Pancreatitis Discrepant?
General Characteristics of Patients with Chronic Pancreatitis
Mortality
Conclusion
References
25 Alcoholic Chronic Pancreatitis and the Impact of Alcohol and Smoking Cessation in Chronic Pancreatitis
Introduction
Epidemiology
Direct Cellular Effects of Alcohol on the Pancreas
Individual Susceptibility to Alcoholic Pancreatitis
Impact of Alcohol and Smoking Cessation
Summary
References
26 What is Relevant on Genetics in Chronic Pancreatitis for Clinical Practice? What Genes and When to Evaluate Them?
Introduction
How to Screen
Probability of Identifying Genetic Variants in CP Patients
Which Genes are Clinically Relevant?
Screening for Cystic Fibrosis Transmembrane Conductance Regulator Gene Variants
What to do When a Variant has been Identified?
Increased Risk for Pancreatic Cancer in Chronic Pancreatitis Patients
How can Genetic Association Studies Change our Clinical Practice?
References
27 Pancreas Divisum and Other Potential Obstructive Causes of Chronic Pancreatitis
Introduction
Idiopathic Pancreatitis
Pancreas Divisum
Other Potential Obstructive Causes of Chronic Pancreatitis
Disclosures
References
28 What to do in Clinical Practice Before Defining a Chronic Pancreatitis as Idiopathic? A Practical Protocol
Introduction
Etiologies of Chronic Pancreatitis
Diagnostic