The Statistical Analysis of Doubly Truncated Data. Prof Carla Moreira
In order to remove the selection bias related to survival, the study was limited to patients diagnosed from PD who had their DNA sample taken within 8 years after onset. Consequently, the age of onset
Clark et al. (2011) divided the cases into an earlier age of onset group (35–55 years) with 99 patients, and a later age of onset group (63–87 years) with 100 patients. The genetic information of these cases, together with basic statistics on the age of onset, is reported in Table 1.5. The early onset group have two patients with missing data on A10398G SNP and on age at sampling, and these are excluded from the analysis.
The Parkinson's Disease Data are used in Chapters 2 and 4. Access to this dataset is possible through the DTDA package, which includes the data frames PDearly and PDlate, for the early and late onset groups, respectively.
1.4.6 Acute Coronary Syndrome Data
We also consider data on the age at diagnosis of acute coronary syndrome (ACS). In Portugal, with a population of 10.3 million inhabitants, there are 38 public hospitals with resources for structured care of patients with ACS, out of which 16 have catheterization laboratory facilities. Public hospitals provide treatment for the majority of the acute coronary events and the number of patients submitted to primary percutaneous coronary intervention increased by 37.0% from 2009 to 2013, although at the regional level access to this procedure varied. The EPIHeart study (Araújo et al., 2018) is a study assembled between August 2013 and December 2014 by the Cardiology Department of two tertiary hospitals in two regions in Northern Portugal: Hospital de São João, Porto, covering the metropolitan area of Porto in the coast; and Hospital de São Pedro, Vila Real, covering the interior, northeastern region. The inclusion criteria to the cohort were admission with confirmed diagnosis of type 1 (primary spontaneous) ACS, aged 18 years or older, and living in the catchment area of the referred hospitals (Porto, Vila Real, Bragança or Viseu). Data were collected through structured interviews within the first 48 hours after admission. Of the 1297 patients initially considered, 939 were included in the cohort due the inclusion criteria (Moreira et al., 2021b). Some descriptive statistics can be found in Table 1.6.
Table 1.6 Descriptive statistics for the ACS Data. Sample size
 |
Mean (SD) | ||
|---|---|---|---|
| Sex | Men | 697 | 62.86 (12.63) |
| Women | 242 | 69.83 (12.59) | |
| Diagnosis | STEMI | 359 | 61.47 (12.82) |
| NSTEMI | 580 | 66.61 (12.69) |
The age at diagnosis
The ACS Data are used in Chapters 2 and 3. This dataset can be obtained from ACS (complete dataset) or ACSred (reduced dataset) in the DTDA package.
References