Biomolecular Engineering Solutions for Renewable Specialty Chemicals. Группа авторов
binds with HbS and helps in increasing its oxygen carrying affinity and thus vanillin has a moderate anti‐sickling property. However, vanillin showed poor oral bioavailability and thus demands for other mode of administration into the body. To overcome this issue, Zhang et al. (2004) synthesized a vanillin prodrug, MX‐1520, which can be biotransformed into vanillin in vivo. Oral administration of MX‐1520 prior to hypoxia exposure in the transgenic sickle mice exhibited significant reduction in the number of sickled cells, which clearly evidenced the potential of MX1520 as a safe antisickling agent for SCD patients.
2.5.5 Hypolipidemic Activity
Vanillin has exerted significant reduction in the levels of serum triglyceride, VLDL‐C, and total cholesterol in high‐fat diet‐induced hyperlipidemic rats (Belagali et al., 2013). Likewise, vanillin‐containing foods showed positive results in reducing obesity in high‐fat diet‐induced obese mice, wherein vanillin reduced abnormal elevation of inflammatory factors including IL‐6 and TNF‐α in plasma and liver tissue results from obesity in high‐fat‐induced mice (Guo et al., 2018).
2.6 Conclusion
The organoleptic compound vanillin has a wide application in number of industries. Among them, vanillin has received much attention by food industry due to its flavoring property. There are three modes of production of vanillin: natural, chemical, and biotechnological synthesis. Only natural and biotechnological vanillin is recommended by food‐safety authorities worldwide. The annual production of vanillin in global market is reported to be 5361 metric tons among which the contribution of natural vanillin is much low. In order to meet the world’s requirement, many advanced biotechnological methods such as strain development, metabolic engineering, genetic engineering, and enzymatic production have been widely investigated. Yet, only very less biotechnological methods have been employed in industries. Thus, applying metabolically engineered strains in industrial production would greatly increase the annual production rate of vanillin.
Acknowledgments
The authors gratefully acknowledge the Indian Council of Medical Research (ICMR), India [No. 5/4/5‐4/Diab.‐16‐NCD‐II], for the financial support to BA. The authors also thank DST‐PURSE, UGC‐UPE, and UGC‐SAP programs of Madurai Kamaraj University for their infrastructure and other facilities.
References
1 Abraham, D. J., Mehanna, A. S., Wireko, F. C., Whitney, J., Thomas, R. P., & Orringer, E. P. (1991). Vanillin, a potential agent for the treatment of sickle cell anemia. Blood, 77, 1334–1341.
2 Achterholt, S., Priefert, H., & Steinbüchel, A. (2000). Identification of Amycolatopsis sp. strain HR167 genes, involved in the bioconversion of ferulic acid to vanillin. Applied Microbiology and Biotechnology, 54, 799–807.
3 Agrawal, R., Seetharam, Y. N., Kelamani, R. C., &Jyothishwaran, G. (2003). Biotransformation of ferulic acid to vanillin by locally isolated bacterial cultures. Indian Journal of Biotechnology, 2(4), 610–612.
4 Alvarado, I. E., Lomascolo, A., Navarro, D., Delattre, M., Asther, M., & Lesage‐Meessen, L. (2001). Evidence of a new biotransformation pathway of p‐coumaric acid into p‐hydroxybenzaldehyde in Pycnoporus cinnabarinus. Applied Microbiology and Biotechnology, 57, 725–730.
5 Andreoni, V., Bernasconi, S., & Bestetti, G. (1995). Biotransformation of ferulic acid and related compounds by mutant strains of Pseudomonas fluorescens. Applied Microbiology and Biotechnology, 42(6), 830–835.
6 Asfour, H. Z. (2018). Anti‐quorum sensing natural compounds. Journal of Microscopy and ultrastructure, 6, 1.
7 Ashengroph, M., Nahvi, I., Zarkesh‐Esfahani, H., & Momenbeik, F. (2010). Optimization of media composition for improving conversion of isoeugenol into vanillin with Pseudomonas sp. strain KOB10 using the Taguchi method. Biocatalysis and Biotransformation, 28, 339–347.
8 Ashengroph, M., Nahvi, I., Zarkesh‐Esfahani, H., & Momenbeik, F. (2011). Pseudomonas resinovorans SPR1, a newly isolated strain with potential of transforming eugenol to vanillin and vanillic acid. New Biotechnology, 28, 656–664.
9 Ashengroph, M., Nahvi, I., Zarkesh‐Esfahani, H., & Momenbeik, F. (2012). Conversion of isoeugenol to vanillin by Psychrobacter sp. strain CSW4. Applied Biochemistry and Biotechnology, 166(1), 1–12.
10 Banerjee, G., & Chattopadhyay, P. (2019). Vanillin biotechnology: the perspectives and future. Journal of the Science of Food and Agriculture, 99, 499–506.
11 Barghini, P., Montebove, F., Ruzzi, M., & Schiesser, A. (1998). Optimal conditions for bioconversion of ferulic acid into vanillic acid by Pseudomonas fluorescens BF13 cells. Applied Microbiology and Biotechnology, 49(3), 309–314.
12 Barghini, P., Di Gioia, D., Fava, F., & Ruzzi, M. (2007). Vanillin production using metabolically engineered Escherichia coli under non‐growing conditions. Microbial Cell Factories, 6, 13.
13 Belagali, Y., Ullal, S. D., Shoeb, A., Bhagwath, V., Ramya, K., & Maskeri, R. (2013). Effect of vanillin on lipid profile in a model of hyperlipidemia, a preliminary study. Indian Journal of Experimental Biology, 51 (4), 288–91.
14 Bloem, A., Bertrand, A., Lonvaud‐Funel, A., & De Revel, G. (2007). Vanillin production from simple phenols by wine‐associated lactic acid bacteria. Letters in Applied Microbiology, 44, 62–67.
15 Bomgardner, M. M. (2016). The Problem with vanilla. Chemical & Engineering News, 94, 38–42.
16 Boz, H. (2015). Ferulic acid in cereals‐a review. Czech Journal of Food Sciences, 33(1), 1–7.
17 Brunati, M., Marinelli, F., Bertolini, C., Gandolfi, R., Daffonchio, D., & Molinari, F. (2004). Biotransformations of cinnamic and ferulic acid with actinomycetes. Enzyme and Microbial Technology, 34, 3–9.
18 Bythrow, J. D. (2005). Vanilla as a medicinal plant. In Seminars in Integrative Medicine 3, 129–131. WB Saunders.
19 del Carmen Martínez‐Cuesta, M., Payne, J., Hanniffy, S. B., Gasson, M. J., & Narbad, A. (2005). Functional analysis of the vanillin pathway in a vdh‐negative mutant strain of Pseudomonas fluorescens AN103. Enzyme and Microbial Technology, 37, 131–138.
20 Chakraborty, D., Gupta, G., & Kaur, B. (2016). Metabolic engineering of E. coli top 10 for production of vanillin through FA catabolic pathway and bioprocess optimization using RSM. Protein Expression and Purification, 128, 123–133.
21 Chattopadhyay, P., Banerjee, G., & Sen, S. K. (2018). Cleaner production of vanillin through biotransformation of ferulic acid esters from agroresidue by Streptomyces sannanensis. Journal of Cleaner Production, 182, 272–279.
22 Converti, A., Aliakbarian, B., Domínguez, J. M., Vázquez, G. B., & Perego, P. (2010). Microbial production of biovanillin. Brazilian Journal of Microbiology, 41, 519–530.
23 Dal Bello, E. (2013). Vanillin production from ferulic acid with Pseudomonas fluorescens BF13‐1p4. PhD thesis, pp.1–128.
24 Das, H., & Singh, S. K. (2004). Useful byproducts from cellulosic wastes of agriculture and food industrya critical appraisal. Critical Reviews in Food Science and Nutrition, 44(2), 77–89.
25 Deep, A., Chaudhary, U., & Gupta, V. (2011). Quorum sensing and bacterial pathogenicity: from molecules to disease. Journal Lab Physicians, 3, 4–11.
26 Deters, M., Knochenwefel, H., Lindhorst, D., Koal, T., Meyer, H. H., Hänsel, W., … & Kaever, V. (2008). Different curcuminoids inhibit T‐lymphocyte proliferation independently of their radical scavenging activities. Pharmaceutical Research, 25(8), 1822–1827.
27 Di Gioia, D., Sciubba, L., Setti, L., Luziatelli, F., Ruzzi, M., Zanichelli, D., & Fava, F. (2007). Production of biovanillin from wheat bran. Enzyme and Microbial Technology, 41(4), 498–505.
28 Dignum, M. J., Kerler, J.,