Enzyme-Based Organic Synthesis. Cheanyeh Cheng
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Enzyme‐Based Organic Synthesis
Cheanyeh Cheng
Department of Chemistry
Chung Yuan Christian University
Chungli
Taiwan
This edition first published 2022
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Library of Congress Cataloging‐in‐Publication Data
Names: Cheng, Cheanyeh, author.
Title: Enzyme‐based organic synthesis / Cheanyeh Cheng, Department of Chemistry, Chung Yuan Christian University, Chungli, Taiwan.
Description: Hoboken, NJ : Wiley, 2022. | Includes bibliographical references and index.
Identifiers: LCCN 2021031980 (print) | LCCN 2021031981 (ebook) | ISBN 9781118027943 (hardback) | ISBN 9781118995143 (adobe pdf) | ISBN 9781118995150 (epub)
Subjects: LCSH: Enzymes–Synthesis. | Organic compounds–Synthesis. | Biocatalysis. | Enzymes–Biotechnology.
Classification: LCC TP248.E5 C44 2021 (print) | LCC TP248.E5 (ebook) | DDC 661/.805–dc23
LC record available at https://lccn.loc.gov/2021031980 LC ebook record available at https://lccn.loc.gov/2021031981
Cover Design: Wiley
Cover Image: Courtesy of author
Preface
The first time I was introduced to the field of microbiology was during the year 1982–1987, when I studied in the United States in the Department of Chemical & Biochemical Engineering of the Graduate and Professional School of Rutgers University to pursue my PhD degree. I was surprised that bacteria can live in an environment without air and at a temperature much higher than room temperature as well as ferment glucose to acetic acid. This study ignited my interest in the research of microorganisms and enzymes. As soon as I finished my PhD study in 1987, I came back to my alma mater, Chung Yuan Christian University, and worked as an associate professor in the Department of Chemistry, the place where I obtained my BS degree in 1974. I decided to continue my PhD research work to study the enzymatic cellulose hydrolysis for producing glucose using raw materials such as waste paper, dead tree branch, or waste bamboo chopsticks and the enantioselective bioreduction of ketones catalyzed by whole yeast cells for producing chiral secondary alcohols. I also taught a course called bioorganic chemistry, which focuses on the chemo‐, stereo‐, and regioselective enzyme or whole microbial cell catalyzed organic synthesis.
Ten years ago, I received an invitation from Wiley to write this book. At that moment I did not realize it is a big challenge for me to write a comprehensive book concerning enzyme‐catalyzed organic synthesis using six classes of enzymes. With the kind of courage that “the newborn calf is not afraid of tigers,” I accepted this invitation and wrote a book writing proposal. Fortunately, my proposal was approved by reviewers and I immediately started writing