Catalytic Asymmetric Synthesis. Группа авторов

Catalytic Asymmetric Synthesis - Группа авторов


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of the Mannich reaction.

      1.3.3. Other Functionalization of the α‐Position of Carbonyl Groups

      Bifunctional organocatalysts are effective not only for the aldol and Mannich reactions but also for functionalization of the α‐position of carbonyl compounds. α‐Fluorination [21], α‐bromination [22], and α‐iodination [23] of aldehydes are successfully carried out by the use of organocatalyst. Azodicarboxylate is used in the α‐amination of aldehydes catalyzed by proline [24]. α‐Aminoxylation of carbonyls is catalyzed by proline [25] and proline salt [26] using nitrosobenzene as an electrophile. These reactions are summarized in the previous book [6].

      1.3.4. Michael Reaction

none

      Source: Based on [27].

      1.3.5. Dienamine and Trienamine as an Intermediate [33]

      1.4.1. Introduction of an Iminium Ion

      1.4.2. Two Reaction Paths


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