Game Changers: What Leaders, Innovators and Mavericks Do to Win at Life. Dave Asprey
decreased social interaction, and changes to the genes for energy metabolism.6 It is not risk free, especially if you use it for fun instead of for personal growth with assistance from trained and experienced experts, or if you use it before your brain is done growing (in your early twenties).
The benefits of LSD are real, however. In two double-blind studies, participants with life-threatening illnesses showed a significant decrease in anxiety after LSD-assisted therapy with no negative side effects or safety issues.7 A meta-analysis of 536 participants taken from studies in the 1950s and 1960s (before the drug became illegal) found that a single dose of LSD significantly decreased alcoholism.8 The effect lasted for many months after the single dose. More recently, a 2006 study found that LSD decreased the intensity and frequency of cluster headaches.9
More relevant to this book, LSD can actually power up your brain. It increases the production of brain-derived neurotrophic factor (BDNF), a powerful protein that stimulates your production of brain cells and strengthens existing ones.10 Studies have found that psychedelics help rabbits learn a new task more quickly.11 We don’t know for sure if this translates to human learning, but it’s promising and may be one reason why psychedelic-assisted therapy helps patients combat depression and post-traumatic stress disorder (PTSD) more effectively than standard therapy does. Other psychedelics, such as mushrooms and ayahuasca (a shamanic brew from South America containing dimethyltryptamine [DMT], which we will discuss later), also raise BDNF. Exercise also increases BDNF; I like to stack my BDNF stimulators for the greatest possible benefit.
Steve Jobs was not the only game changer to have used psychedelics on the quest for self-awareness. Tim Ferriss, the author of The 4-Hour Workweek, The 4-Hour Body, and Tools for Titans, appeared on Bulletproof Radio twice. Tim talked about his experience using ibogaine, an African psychedelic, in a microdosing protocol.
Ibogaine is used by some people as a very mild stimulant. In fact, it was sold in France many years ago for precisely that purpose. Ibogaine has a poor safety record compared to other psychedelics, mostly related to cardiac events. Tim estimates that somewhere between one in a hundred and one in three hundred people who use ibogaine will experience a fatal cardiac event and recommends doing so only under proper medical supervision while hooked up to machines that track your pulse and heart rate. Tim microdosed ibogaine at very low dosages—a range of 2 to 4 milligrams, which is about one-hundredth of a full dose. He experienced a mild prefrontal headache and had a slightly buzzy, very mildly anxious feeling for the first three to four hours. But in that period of time, he did experience heightened attention.
What was most interesting, though, was not what happened on that first day but what happened subsequently. For the next two to three days, Tim reports, his happiness set point was about 15 to 20 percent higher than usual. He also felt highly nonreactive: He was cool and dispassionate and didn’t react emotionally. This is a state he says would normally take him two to three weeks of daily meditation to reach.
Am I suggesting that you microdose ibogaine to increase your performance? Absolutely not. I haven’t tried it and am not planning to because the risk isn’t worth the reward for me. I have young kids. My happiness set point is consistently higher than it ever has been. My flow state comes from service to others, public speaking, EEG neurofeedback, and writing. But again, I believe everyone should have the right to weigh the risks and choose for themselves.
Tim made sure to have medical personnel in attendance when he tried ibogaine, in part because he has witnessed the negative effects of hallucinogens firsthand. When he was much younger, he experimented with LSD, decided to go for a walk, and stepped right into the street. He “came to” standing in the middle of the road at night with headlights bearing down on him. Tim’s cousin, who had a family history of schizophrenia, went from being a super-high-functioning chess whiz to being barely communicative after using LSD. Some medical experts believe that psychedelics can exacerbate or even trigger mental illnesses such as schizophrenia. Yet there are many applications for these drugs, and Tim and I are both glad that many game changers are initiating a responsible conversation about them.
In service of my own growth, I traveled to Amsterdam nineteen years ago to try medical mushrooms, which were legal there. That single experience profoundly changed my brain, drawing my attention to hard-to-find patterns. It taught me to look at the world more closely, and I believe it helped me process some of my own fears that were holding me back and to see the stories I was telling myself so I could start editing them. That’s the real value of this type of medicine. Did taking mushrooms help in my success, and would I do it again? Absolutely, and without reservation.
Note that I was in a country where I could legally use mushrooms. As a biohacker, I make it a point to try everything that might help me raise my limits, but I don’t want to go to jail, either. In 2013, I microdosed LSD for thirty days straight and found the effect to be similar to that of other entirely legal nootropics you’ll read about later in the chapter. I found it’s not worth the legal risk because the rewards weren’t that high for me. If it were free of legal risk, I’d add it to my nootropic stack some of the time.
Even microdosing isn’t without career risk. During my thirty-day experiment, I accidentally took a slightly higher dose than planned one morning. I felt mild elation right before I went onstage in front of a room of about 150 influential executives in Los Angeles to be interviewed about biohacking. Not good. I made it through the interview mostly unscathed, although I cracked a couple jokes that weren’t funny to anyone except me. If the dose had been even a little bit higher, who knows what else I would have said? Even when you’re far from high, your judgment may be altered when microdosing, and you won’t know it until later.
And yes, I go to Burning Man and greatly value my experiences there, some of which may include full-dose psychedelics. When they do, it’s always with people who are there to make it safe (including medical professionals), and I walk away better off. More on full-dose experiences later. The bottom line is that microdosing psychedelics is neither a panacea for personal growth and performance nor entirely useless and dangerous. Psychedelics can heal. They can harm. At very low doses, they can increase your performance. If you decide to use them, start slowly, do so with a trusted person, do so for the first time when you’re not planning a big day at work, and do so in a legal jurisdiction. These aren’t party drugs.
You also can’t expect to pop a pill and suddenly possess new levels of self-awareness. When used appropriately, these drugs can activate an elevated consciousness that triggers new insights, but to truly cultivate self-awareness, you still have to do the work. In other words, drugs in and of themselves won’t make you more aware, but they can give you the opportunity to see the things you need to work on. It’s up to you to then take action and work on them!
But microdosing psychedelics is far from the only way to benefit from certain drugs. I have actively benefited from another class of drugs, nootropics, since 1997, when I was grappling with a steep decline in my cognitive performance at work. When my doctor was ill equipped to help, I took matters into my own hands and ordered almost $1,000 worth of smart drugs from Europe (the only place where you could get them at the time). I remember opening the unmarked brown package and wondering whether the contents would actually improve my brain. They did, and I’ve been a big fan of certain cognitive enhancers ever since.
Like psychedelics, smart drugs won’t automatically blanket you in self-awareness. Finding self-awareness takes energy. Anytime you can give yourself better cellular function, more energy, increased neuroplasticity, and improved learning abilities (which many of these drugs do), it makes gaining self-awareness easier. You can progress more quickly if you’re running on high power.
The trouble with using a blanket term such as nootropics is that it lumps all kinds of substances together. Technically, you could argue that caffeine and cocaine are both nootropics, but they’re hardly equal. With so many