Wheat Belly. William MD Davis
naloxone.
Let’s pretend you’re an inner-city heroin addict. You get knifed during a drug deal gone sour and get carted to the nearest A&E. Because you’re high on heroin, you kick and scream at the staff trying to help you. So these nice people strap you down and inject you with a drug called naloxone, and you are instantly not high. Through the magic of chemistry, naloxone immediately reverses the action of heroin or any other opiate drug such as morphine or oxycodone.
In lab animals, administration of naloxone blocks the binding of wheat exorphins to the morphine receptor of brain cells. Yes, opiate-blocking naloxone prevents the binding of wheat-derived exorphins to the brain. The very same drug that turns off the heroin in a drug-abusing addict also blocks the effects of wheat exorphins.
In a World Health Organization study of thirty-two schizophrenic people with active auditory hallucinations, naloxone was shown to reduce hallucinations.12 Unfortunately, the next logical step – administering naloxone to schizophrenics eating a ‘normal’ wheat-containing diet compared to schizophrenics administered naloxone on a wheat-free diet – has not been studied. (Clinical studies that might lead to conclusions that don’t support drug use are often not performed. In this case, had naloxone shown benefit in wheat-consuming schizophrenics, the unavoidable conclusion would have been to eliminate wheat, not prescribe the drug.)
The schizophrenia experience shows us that wheat exorphins have the potential to exert distinct effects on the brain. Those of us without schizophrenia don’t experience auditory hallucinations from exorphins resulting from an onion bagel, but these compounds are still there in the brain, no different than in a schizophrenic. It also highlights how wheat is truly unique among grains, since other grains such as millet and flax do not generate exorphins (since they lack gluten), nor do they cultivate obsessive behaviour or withdrawal in people with normal brains or people with abnormal brains.
So this is your brain on wheat: digestion yields morphine-like compounds that bind to the brain’s opiate receptors. It induces a form of reward, a mild euphoria. When the effect is blocked or no exorphin-yielding foods are consumed, some people experience a distinctly unpleasant withdrawal.
What happens if normal (i.e., nonschizophrenic) humans are given opiate-blocking drugs? In a study conducted at the Psychiatric Institute of the University of South Carolina, wheat-consuming participants given naloxone consumed 33 per cent fewer calories at lunch and 23 per cent fewer calories at dinner (a total of approximately 400 calories less over the two meals) than participants given a placebo.13 At the University of Michigan, binge eaters were confined to a room filled with food for one hour. (There’s an idea for a new TV show: The Biggest Gainer.) Participants consumed 28 per cent less wheat crackers, bread sticks and pretzels with administration of naloxone.14
In other words, block the euphoric reward of wheat and calorie intake goes down, since wheat no longer generates the favourable feelings that encourage repetitive consumption. (Predictably, this strategy is being pursued by the pharmaceutical industry to commercialise a weight loss drug that contains naltrexone, an oral equivalent to naloxone. The drug is purported to block the mesolimbic reward system buried deep within the human brain that is responsible for generating pleasurable feelings from heroin, morphine and other substances. Pleasurable feelings can be replaced by feelings of dysphoria, or unhappiness. Naltrexone will therefore be combined with the antidepressant and smoking-cessation drug bupropion.)
From withdrawal effects to psychotic hallucinations, wheat is party to some peculiar neurological phenomena. To recap:
Common wheat, upon digestion, yields polypeptides that possess the ability to cross into the brain and bind to opiate receptors.
The action of wheat-derived polypeptides, the so-called exorphins such as gluteomorphin, can be short-circuited with the opiate-blocking drugs naloxone and naltrexone.
When administered to normal people or people with uncontrollable appetite, opiate-blocking drugs yield reductions in appetite, cravings, and calorie intake, as well as dampen mood, and the effect seems particularly specific to wheat-containing products.
Wheat, in fact, nearly stands alone as a food with potent central nervous system effects. Outside of intoxicants such as ethanol (like that in your favourite merlot or chardonnay), wheat is one of the few foods that can alter behaviour, induce pleasurable effects and generate a withdrawal syndrome upon its removal. And it required observations in schizophrenic patients to teach us about these effects.
NIGHT CRAVINGS CONQUERED
For as long as he could remember, Larry struggled with weight.
It never made sense to him. He exercised, often to extremes. A 50-mile bike ride was not unusual, nor was a 15-mile walk in the woods or desert. As part of his work, Larry enjoyed the terrain of many different areas of the United States. His travel often took him to the southwest, where he hiked for up to six hours. He also prided himself on following a healthy diet: limiting his red meat and oils and eating plenty of vegetables and fruit and, yes, an abundance of ‘healthy whole grains’.
I met Larry because of a heart rhythm problem, an issue we dealt with easily. But his blood work was another issue. In short, it was a disaster: blood glucose in the low diabetic range, triglycerides too high at 210 mg/dl, HDL too low at 37 mg/dl, and 70 per cent of his LDL particles were the small heart disease-causing type. Blood pressure was an important issue with systolic (‘top’) values ranging up to 170 mmHg and diastolic (‘bottom’) values of 90 mmHg. Larry was also, at 5 feet 8 inches and 17 stone 5 pounds, nearly 6 stone overweight.
‘I don’t get it. I exercise like nobody you know. I really like exercise. But I just cannot – cannot – lose the weight, no matter what I do.’ Larry recounted his diet escapades that included an all-rice diet, protein drink programmes, ‘detox’ regimens, even hypnosis. They all resulted in a few pounds lost, only to be promptly regained. He did admit to one peculiar excess: ‘I really struggle with my appetite at night. After dinner, I can’t resist the urge to graze. I try to graze on the good stuff, like whole-wheat pretzels and these multigrain crackers I have with a yoghurt dip. But I’ll sometimes eat all night from dinner until I go to bed. I don’t know why, but something happens at night and I just can’t stop.’
I counselled Larry on the need to remove the number one most powerful appetite stimulant in his diet: wheat. Larry gave me that ‘not another kooky idea!’ look. After a big sigh, he agreed to give it a go. With four teenagers in the house, clearing the shelves of all things wheat was quite a task, but he and his wife did it.
Larry returned to my office six weeks later. He reported that, within three days, his nighttime cravings had disappeared entirely. He now ate dinner and was satisfied with no need to graze. He also noticed that his appetite was much smaller during the day and his desire for snacks virtually disappeared. He also admitted that, now that his craving for food was much less, his calorie intake and portion size was a fraction of its former level. With no change in his exercise habits, he’d lost ‘only’ eleven pounds. But, more than that, he also felt that he’d regained control over appetite and impulse, a feeling he thought he’d lost years earlier.
WHEAT: APPETITE STIMULANT
Crackheads and heroin addicts shooting up in the dark corners of an inner-city drug house have no qualms about ingesting substances that mess with their minds. But how about law-abiding citizens like you and your family? I’ll bet your idea of mind bending is going for the strong brew rather than the mild stuff at Starbucks, or hoisting one too many Heinekens on the weekend. But ingesting wheat means you have been unwittingly ingesting the most common dietary mind-active food known.
In effect, wheat is an appetite stimulant: it makes you want more – more cookies, cupcakes, pretzels, candy, soft drinks. More bagels, muffins, tacos, submarine sandwiches, pizza. It makes you want both wheat-containing and non-wheat-containing foods. And, on top of that, for some people wheat is a drug, or at least yields peculiar drug-like neurological effects that can be reversed with medications used to counter the effects of narcotics.
If you balk at the notion of being dosed with a drug such as