Understanding Clinical Papers. David Bowers
rel="nofollow" href="#ulink_18ae6438-8827-588a-9e6a-5f1698e27eba">Figure 3.4 The aim of the qualitative study.
Source: From Jones et al. (2009), © 2009 Elsevier.
A particular type of objective is to develop new hypotheses for testing in future research, so‐called hypothesis‐generating. Sometimes hypotheses are generated by subgroup analysis and post‐hoc examinations of the data produced by quantitative research (Figure 3.5). Hypothesis generation of this sort should be regarded as unreliable, but, for all that, it may produce interesting ideas. Be careful to look out for it, because some authors present these as established results rather than ideas for future work.
Figure 3.5 New subgroup analysis in report of an RCT.
Source: Reproduced from O'Connor et al. (2017). Licensed under CC BY 4.0.
STUDIES WITH UNCLEAR OBJECTIVES
If you cannot find a mention of the study's objectives expressed as aims or specific questions, you may yet be able to find them expressed in less clear‐cut ways. Examples include ‘exploring associations' or (worse) ‘examining issues'. You will need to be particularly careful about studies with such vague objectives: because they are not asking a specific question, it is not easy to tell whether the results are meaningful. Quantitative studies with unclear prior questions can produce results that are due to chance – especially as a result of post‐hoc or multiple testing. Qualitative studies, when they start without a clear question, do not tend to produce misleading results as much as uninteresting ones.
As a final note, we want to say something about why we think it's worth so much effort to clarify the exact aims and objectives of a study. To do so, we will outline a small thought experiment. Suppose you are working as a general medical practitioner and a mother brings a child to you, saying she is worried that he is not growing and is shorter than all his peers. The appropriate initial response would be a piece of quantitative research to answer the question: ‘Is this boy short for his age?' You would measure his height, checking it against suitable norms.
Suppose now you see another child whose mother is worried that he seems unhappy and withdrawn, but she does not understand why that should be. You are likely to want to undertake some qualitative research – asking him in a relaxed and unstructured but purposeful way whether he does indeed feel unhappy, and if so why? In other words you match the design of your inquiry to the question you are asking. Now, it would be possible to have a chat with the first boy and ask him his experiences of growing up and being (perhaps) on the short side, and you could give the second child an age‐appropriate standardized mood rating scale. You will have produced results but not answers because in neither case would your method of inquiry be appropriate to your (or the mother's) specific prior questions.
These examples introduce another question often asked of researchers: where do the aims and objectives come from? Of course, the answer is often that they come from gaps in our knowledge or theories. However, another interesting possibility is that they come from, or at least are influenced by, the views and experiences of people with personal experience of the condition being researched. This is one of the main functions of what is often called Public and Patient Involvement (PPI for short) in research – making sure that the objectives of research and the way those objectives are met will be of relevance to the ultimate consumers of research findings.
We hope that when you read research reports you will therefore have in mind your own queries: are the aims and objectives clear, and is the researchers' chosen method the best one to meet their aims and objectives?
CHAPTER 4 Descriptive Studies: Qualitative
Once you are clear about the aims and objectives of a study, and any hypotheses that have been posed, the next important question to ask is: ‘What sort of study did the authors undertake?' The various kinds of study design that are commonly found in clinical journals form the subject of this chapter and Chapters 5–11 – starting here with qualitative studies. Quantitative research, and its subcategories of design, is described across Chapters 5–7. Chapter 8 goes on to describe so‐called mixed methods studies, where the qualitative and quantitative approaches are combined in various ways, and Chapter 9 singles out what are called complex intervention studies for particular attention. The last two chapters in this section (Chapters 10 and 11) deal with reviewing and combining primary research studies to form secondary reviews.
QUALITATIVE RESEARCH
Qualitative research has proliferated greatly since the 1990s as a method for investigating illness and healthcare, becoming a regular feature in most good clinical journals. In general, the method involves observation of people's experience of illness and of healthcare, or examines how they are managing ill‐health or diagnostic investigation, without attempts to manipulate or alter either health or its care – an approach sometimes called naturalistic research. The data collected, analysed, and described in the report of a qualitative study will be based on words rather than numbers. These data are usually collected by way of carefully arranged conversations with the people concerned or, less often, from diaries or other accounts, or through direct observation of their experiences.
Typically, qualitative research sets out aims but not hypotheses, tending to explain experiences or events but not to predict what may happen to other people. The pursuit of hypotheses in research (see Chapter 3) tends to be a feature of investigations that involve some kind of comparison: does some action (e.g. smoking) make certain illnesses more likely or is one treatment (e.g. an antibiotic) more effective than another? These kinds of hypothesis‐driven studies form the quantitative analytic and intervention studies of the kind that are introduced in Chapters 6 and 7. Qualitative research, on the other hand, offers invaluable insights when little is known about a topic, in particular where it is important to know about people's attitude towards healthcare. For example, common topics for qualitative enquiry concern people's views about whether to undergo tests or procedures and the effects of treatments on people's lives. An example is shown in Figure 4.1, where women who had a strong family history of breast cancer were asked about gene testing, whether they might consider prophylactic mastectomy in order to avoid cancer and, for some of the women, their experience of mastectomy and reconstruction. The research pointed to a need for improved information and support for women in this predicament – at multiple stages of a complex pathway of decisions, procedures, care, and resumption of lifestyle.