Mount Sinai Expert Guides. Группа авторов

       ICU‐related complications can increase morbidity, mortality, and socioeconomic costs of the critically ill patient.

       The occurrence of adverse events related to invasive procedures and medications carries significant consequences particularly in the ICU where these procedures are frequently performed.

       Familiarity with specific complications and their management can help reduce the rate of adverse events.

       Pain, anxiety, agitation, and PTSD have been widely studied in ventilated patients in the ICU. No one sedative agent has been reported to improve the risk of mortality among the critically ill or injured when compared in randomized control trials. For example, propofol may be associated with a shorter time to extubation and recovery from sedation when compared with midazolam. However, the risk of hypertriglyceridemia and hypotension is higher with propofol.

       Propofol has also been associated with propofol‐related infusion syndrome (PRIS) which includes worsening metabolic acidosis, rhabdomyolysis, hypertriglyceridemia, hypotension, and arrhythmias. Some risk factors for PRIS are:High propofol doses.Prolonged infusion.Liver disease.Use of vasopressors.Underlying mitochondrial disease.

       Dexmedetomidine has been linked to a lower risk of drug‐associated delirium than alternative sedative agents, but it increases risk of bradycardia and hypotension.

       Only a minority of critically ill patients require deep sedation, for conditions such as severe respiratory failure (e.g. ARDS), intracranial hypertension, and refractory status epilepticus.

        Daily sedation interruption and use of sedation scales to target light sedation have been shown to reduce ventilator time and ultimately LOS. The Richmond Agitation‐Sedation Scale (RASS) and Riker Sedation‐Agitation Scale (see Chapter 2) have the best reliability and are recommended by clinical practice guidelines.

       Critical illness polyneuropathy (CIP) and myopathy (CIM) are major complications of severe critical illness and its management. CIP/CIM affects both motor and sensory axons and, as a consequence, can prolong weaning from mechanical ventilation and physical recovery. Sepsis, systemic inflammatory response syndrome, and multiple organ failure play a crucial role in CIP/CIM. Prevention of risk factors such as high dose steroids, prolonged neuromuscular blockade, prolonged immobility, treatment of the underlying critical illness, and supportive care are the mainstay of treatment. Early mobilization and physical therapy in the ICU have been shown to prevent, as well as aid in treatment of, CIP. Early rehabilitation in the ICU is safe and associated with several benefits, including improvements in muscle strength, functional mobility, quality of life, and reduction in ICU delirium.

       Bedside TTE use has gained popularity since the 1990s and has now become an important instrument in assessing the cause of and appropriate response to most hemodynamic disturbances.

       We recommend the early use of goal‐directed bedside TTE in patients with hemodynamic instability, particularly those with increasing need of hemodynamic support to identify underlying treatable causes and help guide fluid resuscitation. Cardiac ultrasound allows intensivists to narrow the differential diagnosis and rapidly diagnose and initiate treatment.

       Cardiac arrhythmias are a commonly encountered problem in the ICU. Preventable factors leading to arrhythmias include electrolyte abnormalities, catecholamine excess, and drug‐related adverse effects. Patients should be closely monitored for signs of cardiac ischemia with ECG and cardiac biomarkers. ECG monitoring for QT prolongation with close follow‐up can help in avoiding arrhythmias such as torsades de pointes.

       QTc intervals should be particularly monitored in those receiving medications such as procainamide, amiodarone, certain antibiotics (erythromycin, pentamidine, ketoconazole), tricyclic antidepressants, and haloperidol.

       Lastly, electrolyte abnormalities, particularly in hypokalemia, hypocalcemia, and hypomagnesemia, should be aggressively and appropriately repleted to prevent and often treat certain arrhythmias.

       Blood transfusions are commonly administered to critically ill patients. Previous practices maintained hemoglobin thresholds of >10 g/dL in the critically ill. Recent guidelines based on multicenter randomized control trials indicate that target hemoglobin values of 7–8 g/dL are associated with equivalent or better outcomes in many patient populations and reduce the risk of infection, transfusion reactions and volume overload.

       The 2016 American Association of Blood Banks (AABB) guidelines include the following recommendations for hemodynamically stable patients without active bleeding:

       Hemoglobin <6 g/dL: transfusion recommended.

       Hemoglobin 6–7 g/dL: transfusion generally likely to be indicated.

       Hemoglobin 7–8 g/dL: transfusion may be appropriate in patients undergoing orthopedic surgery or cardiac surgery, and in those with stable cardiovascular disease, after evaluating the patient’s clinical status.

       Hemoglobin 8–10 g/dL: transfusion generally not indicated, but considered for some (e.g. symptomatic anemia, bleeding, acute coronary syndrome with ischemia, and hematology/oncology patients with severe thrombocytopenia who are at risk of bleeding).

       Hemoglobin >10 g/dL: transfusion generally not indicated except in exceptional circumstances.

       Critically ill patients pose an increased risk of developing venous thromboembolism (VTE) due to their increased length of hospitalization, inactivity, immobilization, and often hypercoagulable states. Mortality associated with deep venous thrombosis is significantly high and often progresses to more serious complications such as pulmonary embolism.

       Prophylaxis for VTE should be considered in all patients and initiated at the time of admission. The majority of ICU patients fall under the high risk criteria for developing VTE and pulmonary embolism, particularly those patients who have had an operation or have had major trauma. These patients should be initiated on prophylaxis with low dose unfractionated