Principles of Virology. Jane Flint
Togaviruses Glossary Index
3
Volume II
Preface
Acknowledgments
About the Authors
Key of Repetitive Elements
1 Infections of Populations: History and Epidemiology
Introduction to Viral Pathogenesis
A Brief History of Viral Pathogenesis
Viral Epidemics in History
Epidemiology
Parameters That Govern the Ability of a Virus to Infect a Population
Perspectives
References
2 Barriers to Infection
Introduction
An Overview of Infection and Immunity
Successful Infections Must Modulate or Bypass Host Defenses
Viral Tropism
Spread throughout the Host
Organ Invasion
Shedding of Virus Particles
Perspectives
References
3 The Early Host Response: Cell Autonomous and Innate Immunity
Introduction
The First Critical Moments: How Do Individual Cells Detect a Virus Infection?
Cell-Intrinsic Defenses
Secreted Mediators of the Innate Immune Response
The Innate Immune Response
Perspectives
References
4 Adaptive Immunity and Establishment of Memory
Introduction
Attributes of the Host Response
Lymphocyte Development, Diversity, and Activation
Events at the Site of Infection Set the Stage for the Adaptive Response
Antigen Processing and Presentation
The CTL (Cell-Mediated) Response
The Humoral (Antibody) Response
Immunological Memory
Perspectives
References
5 Patterns and Pathogenesis
Introduction
Animal Models of Human Diseases
Patterns of Infection
Viral Virulence
Pathogenesis
Perspectives
References
6 Cellular Transformation and Oncogenesis
Introduction
Oncogenic Viruses
Activation of Cellular Signal Transduction Pathways by Viral Transforming Proteins
Disruption of Cell Cycle Control Pathways by Viral Transforming Proteins
Transformed Cells Increase in Size and Survive
Tumorigenesis Requires Additional Changes in the Properties of Transformed Cells
Other Mechanisms of Transformation and Oncogenesis by Human Tumor Viruses
Perspectives
References
7 Vaccines
Introduction
The Origins of Vaccination
Vaccine Basics
The Science and Art of Making Vaccines
Vaccine Technology: Delivery and Improving Antigenicity
The Ongoing Quest for an AIDS Vaccine
Perspectives
References
8 Antiviral Drugs
Introduction
Discovering Antiviral Compounds
Drug Resistance
Examples of Antiviral Drugs
Expanding