Immunology. Richard Coico
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IMMUNOLOGY
A Short Course
EIGHTH EDITION
Richard Coico
SUNY Downstate College of Medicine, Brooklyn, New York
This edition first published 2021
© 2021 John Wiley & Sons Ltd
Edition History
John Wiley & Sons Ltd (7e, 2015)
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Library of Congress Cataloging‐in‐Publication Data
9781119551577
Cover image: Antibodies attacking virus particles, illustration © CHRISTOPH BURGSTEDT / science source
Cover design by Wiley
To Lisa, Jonathan, and Jennifer
ABOUT THE AUTHOR
Richard Coico is Professor of Cell Biology and Medicine and Director of the Clinical and Translational Science Center at SUNY Downstate Health Sciences University in Brooklyn New York. His teaching experience has spanned major public and private academic medical centers where he has directed medical school courses and participated in innumerable medical education curriculum activities. He is past‐President of the Association of Medical School Microbiology and Immunology Chairs (AMSMIC) organization and, during his tenure as a department Chair, he served on and chaired AMSMIC’s medical education committee. Throughout his career, his research interests have concerned the study of the physiological role of IgD—a B‐cell membrane immunoglobulin co‐expressed with IgM—and computational approaches to the identification of candidate vaccines for several hemorrhagic viruses, including Ebola and Lassa fever viruses.
CONTRIBUTORS
Philip L. Cohen Temple University School of Medicine, Philadelphia, Pennsylvania
Susan R.S. Gottesman Department of Pathology, SUNY Downstate University of Health Sciences, College of Medicine, Brooklyn, New York
PREFACE AND ACKNOWLEDGMENTS TO THE EIGHTH EDITION
The 8th edition of Immunology: A Short Course preserves our commitment to the motto less is more. Since the publication of the 7th edition, our knowledge of how the immune system develops and functions and ways in which these physiological phenomena can fail or be compromised and thereby cause disease has significantly expanded. To reflect this new knowledge, many important updates and changes in chapters (including new ones) appear in this edition. The 8th edition includes new chapters on cells and organs of the immune system (Chapter 2), organization and expression of lymphocyte antigen receptor genes (Chapter 8), and experimental systems and methods (Chapter 20). The subjects of B‐ and T‐cell development activation are covered in two new chapters, each dealing with these respective lymphocyte populations. Every other chapter and appendix section that appeared in the 7th edition has been significantly updated and, in particular, the chapter on tumor immunology (18) has been completely rewritten by one of the contributing authors (SG).
Recent advances in immunology have led to a better understanding of the human immune system and the mechanisms of infectious and immune‐mediated diseases. The immune system is essential for survival in the face of pathogens. In some cases, however, immune responses to pathogens can result in exaggerated, harmful outcomes (e.g., cytokine storms that induce perinflammatory responses).