Essential Endocrinology and Diabetes. Richard I. G. Holt
of Biology, Medicine and Health
University of Manchester, Manchester, UK
Seventh Edition
This edition first published 2021
© 2021 John Wiley & Sons Ltd
Edition History Wiley‐Blackwell (6e, 2012)
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Library of Congress Cataloging‐in‐Publication Data
Names: Holt, Richard I. G., author. | Hanley, Neil A., author.
Title: Essential endocrinology and diabetes / Richard I.G. Holt, Neil A. Hanley.
Other titles: Essentials (Wiley‐Blackwell (Firm))
Description: Seventh edition. | Hoboken, NJ : John Wiley & Sons, Inc., 2021. | Series: Essentials | Includes bibliographical references and index.
Identifiers: LCCN 2020044319 (print) | LCCN 2020044320 (ebook) | ISBN 9781118763964 (paperback) | ISBN 9781118764138 (adobe pdf) | ISBN 9781118764121 (epub)
Subjects: MESH: Endocrine Glands–physiology | Hormones–physiology | Endocrine System Diseases | Diabetes Mellitus
Classification: LCC RC649 (print) | LCC RC649 (ebook) | NLM WK 100 | DDC 616.4–dc23
LC record available at https://lccn.loc.gov/2020044319 LC ebook record available at https://lccn.loc.gov/2020044320
Cover Design: Wiley
Cover Image: © JOHN BAVOSI/Science Source
Preface
Welcome to the latest edition of Essential Endocrinology & Diabetes. We are delighted that the previous edition was so well received around the world, selling over 5600 copies. The book also had the dubious honour of being the most frequently stolen book from the University of Southampton medical school library suggesting that the medical students, in Southampton at least, found it a useful accompaniment to their endocrinology and diabetes course. However, it is time for an update and a refresh that captures the latest research, clinical guidelines, investigational modalities and therapies. We hope you enjoy the new content.
The textbook aims to be valued by different groups of reader. Its core purpose is still to provide a foundation from understanding the science to clinical training in undergraduate medicine. In addition, the content here should also be invaluable for postgraduate clinicians training in the speciality of endocrinology and diabetes. Written ‘exit’ examinations have become increasingly common during the later stages of clinical speciality training and we hope our textbook provides complementary study material alongside larger reference textbooks and published clinical guidelines. From feedback, we realise that our book has been valued by biomedical undergraduate and masters students and by those pursuing clinical biochemistry. We hope the new content increases this reach across different audiences. Learning objectives, recap points, cross‐referencing guides, boxes, and concluding key points help orientate the reader and emphasize the major topics.
Based on the success of previous editions, the book is still structured in much the same way. The first part is designed to create a knowledgeable reader, well prepared for the clinical sections or for more specific scientific study. To assist the many students coming from non‐scientific backgrounds we limit assumptions on prior knowledge. Chapter 1 still covers the core principle of feedback regulation which underlies nearly all endocrine physiology and is vital for the correct interpretation of many clinical tests. Chapter 3 has advanced to encompass the latest research made possible from next‐generation sequencing technology. The latter has already started to impact significantly on clinical investigation and diagnostics in endocrinology and diabetes. This is covered in Chapter 4, which also includes positron emission tomography (PET) imaging. It is important that aspiring clinicians, as well as scientists, appreciate these new approaches, their application and their challenges. The second part of the book still follows its organ or system‐based approach. We have retained the more specific scientific knowledge at the start of these chapters to underpin understanding, diagnosing and managing the relevant clinical disorders. The third part on diabetes and obesity has seen the greatest change from the previous edition. Over the last 8 years, there have been significant advances in the treatment of both type 2 diabetes, such as an expansion of the indications for incretin‐based therapies and the introduction of the SGLT2 inhibitors, and type 1 diabetes with the development of better insulins and the use