Surface Science and Adhesion in Cosmetics. Группа авторов
Sample 8 (CAP Acrylate (0.25) might be a good candidate for GAL-FL or LED. (Control)1: Not formulated, (DS): degree of substitution per glucose ring.
Table 3.10 Lag time (the time that the coating was on the nail), steady-state flux, permeability coefficient, diffusion coefficient and amount of drug in nail clippings.
| Formulation | Lag time (day) | Steady-state flux (μg/cm2/day) | Permeability coefficient × 10-5 (cm/day) | Diffusion coefficient × 10-5 (cm2/day) | Drug in nail clipping (μg/cm2) |
| Curanail film (32 wt.% Amorolfine HCl) | 10.4 ± 1.3 | 2.9 ± 0. 2 | 5.8 ± 0.3 | 2.5 ± 0.5 | 61.1 ± 14.8 |
| 3 wt.% Amorolfine HCl UV-cured film | 10.4 ± 0.9 | 2.4 ± 0.2 | 7.9 ± 0.7 | 2.7 ± 0.8 | 37.5 ± 17.6 |
| 4 wt.% Terbinafine HCl UV-cured film | 9.5 ± 1.2 | 1.5 ± 0.1 | 3.7 ± 0.3 | 1.6 ± 0.4 | 71.1 ± 8.0 |
| Statistical difference between Curanail and Amorolfine UV-cured film? | No (p>0.05) | Yes (p<0.05) | Yes (p<0.05) | No (p>0.05) | Yes (p<0.05) |
| Statistical difference between Amorolfine and Terbinafine UV-cured film? | No (p>0.05) | Yes (p<0.05) | Yes (p<0.05) | Yes (p<0.05) | Yes (p<0.05) |
Figure 3.19 UV nail gel construction: Human nail, UV nail gel base coat which is used primarily to obtain adhesion to the human nail and to even out irregularities of the surface, UV nail gel color coat or clear coat that can result in multiple shades or clear to show the natural color of the nail, and UV nail gel top coat that ultimately results in the performance layer of the nail.
3.12 UV-Cured Nail Gel Safety
As one can see in Figure 3.19 the UV nail gel technology is applied to the human nail in built-up layers. The base coat is primarily used to obtain adhesion to the human nail and to even out irregularities of the nail surface. The next layer (intermediate coat) is the color coat that can result in multiple number of shades. However, this layer (intermediate coat) can be used without pigmentation which results in a clear coat that exhibits the natural color of the nail. The final layer is the top coat and this ultimately is the performance layer of the nail. Concerns for safety of the UV nail gel technology can be seen in two specific areas; 1) the UV cure light exposure, and 2) acrylated oligomers, acrylated monomers and PIs used in the formulation of the UV nail gel technology.