Understanding Platelet-Rich Fibrin. Richard J. Miron

Understanding Platelet-Rich Fibrin - Richard J. Miron

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      Understanding Platelet-Rich Fibrin


       Library of Congress Cataloging-in-Publication Data

      Names: Miron, Richard J. (Richard John), 1983- editor.

      Title: Understanding platelet-rich fibrin / edited by Richard J. Miron.

      Description: Batavia, IL : Quintessence Publishing Co Inc, [2021] | Includes bibliographical references and index. | Summary: "This book outlines the science behind platelet-rich fibrin and then details how to use it in clinical practice to optimize healing outcomes and promote tissue regeneration. Applications include gingival recessions, intrabony and furcation defects, extraction site management, implant dentistry, guided bone regeneration, sinus grafting, oral and maxillofacial surgery, regenerative endodontics, facial esthetics, and medicine"--Provided by publisher.

      Identifiers: LCCN 2020035734 | ISBN 9781647240493 (hardcover)

      Subjects: MESH: Platelet-Rich Fibrin | Fibrin--therapeutic use | Tissue Engineering | Bone Regeneration

      Classification: LCC QP91 | NLM WH 400 | DDC 612.1/15--dc23

      LC record available at https://lccn.loc.gov/2020035734


      ©2021 Quintessence Publishing Co, Inc

      Quintessence Publishing Co, Inc

      411 N Raddant Road

      Batavia, IL 60510


      5 4 3 2 1

      All rights reserved. This book or any part thereof may not be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, or otherwise, without prior written permission of the publisher.

      Editor: Leah Huffman

      Design: Sue Zubek

      Production: Angelina Schmelter

      Printed in the USA



       4Understanding Relative Centrifugal Force (G-Force)

       5Protocols for PRF

       6Importance of Centrifugation Tubes for the Production of PRF

       7Biologic Characterization of e-PRF Membranes

       8Armamentarium in a PRF Kit


       10Fabricating Various PRF Modalities

       11Overview of Clinical Indications Using PRF


       12Use of PRF for the Treatment of Gingival Recessions

       13Use of PRF for the Treatment of Intrabony and Furcation Defects

       14Use of PRF for Extraction Site Management


       15Use of PRF as an Adjunct Therapy to Implant Dentistry

       16Use of PRF in Guided Bone Regeneration

       17Use of PRF for Sinus Grafting


       18Use of PRF in Oral and Maxillofacial Surgery

       19Use of PRF in Regenerative Endodontics

       20Use of PRF in Facial Esthetics

       21Medical Uses of PRF

       22Future Research with PRF



      I would like to dedicate this textbook specifically to Dr Fatiha Chandad and the Dental Faculty at the University of Laval in Quebec, Canada, who devoted countless hours to training students like me in dentistry.

      Dr Chandad, Dean of Dental Research, was someone who motivated me and more importantly made it possible for students to work within her laboratory on research projects during their 4 years of dental studies. It was here that I first started my research activities on PRP/PRF and became fascinated with research as a whole. Dr Chandad is one of the only people I have ever met never wanting to be recognized for her achievements, instead insisting that her students be recognized and at the forefront of their own success. It was during these times that I was awarded the prestigious Hatton Award in Canada and was later named the IADR Young Investigator of the Year in Implant Dentistry.

      In appreciation of her contributions to my career, 100% of the royalties from this textbook will be donated to create a scholarship named after her for new dental graduates at the University of Laval. Milles fois merci pour tout tes efforts!

      Many important medical/dental discoveries were stumbled upon by pure chance. An example of this is osseointegration, which launched the modern era of dental implants and orthopedic-embedded prostheses. It occurred when orthopedic researcher Per-Ingvar Brånemark found that his titanium research cages in sheep were so completely ingrown with bone that he couldn’t remove them. Similarly, platelet-rich plasma (PRP)/platelet-rich fibrin (PRF) was discovered by the serendipity of observing accelerated and more complete healing in patients who developed hematomas. From that simple observation in the 1980s, the components of the blood clot responsible for the advanced healing have since been determined to be the complete and active growth factors in the alpha granules of viable platelets

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