Pet-Specific Care for the Veterinary Team. Группа авторов
3.7.4 Genetic Health Registries
Many owners and veterinarians wonder if a particular medical issue observed in a companion animal is genetically controlled and related to its breed, sex, growth rate and size, age, or diet. Health registries can help answer those questions. In their simplest form, genetic health registries are repositories of the results obtained from either phenotypic or genetic health screening tests (see 3.4 Predicting and Eliminating Disease Traits). By recording and compiling the information in an accessible formant, owners, breeders, and veterinary practitioners can use that to inform decisions. Genetic health registries provide an important resource for the veterinary community by cataloging diseases of a population of animals (Table 3.7.1), permitting the development of informed treatment plans, and illuminating trends of emerging diseases.
Table 3.7.1 The top 11 breeds with the highest prevalence of elbow dysplasia by breed for those breeds with at least 50 evaluations from 1974 thru 2018
Source: Data from the OFA Canine Health Information Center health registry (www.ofa.org).
| Breed | Rank | Number of evaluations | % Normal | % Overall dysplastic | % Grade 1 dysplasia | % Grade 2 dysplasia | % Grade 3 dysplasia |
|---|---|---|---|---|---|---|---|
| Chow chow | 1 | 1248 | 50 | 49 | 25 | 17 | 6 |
| Pug | 2 | 216 | 59 | 41 | 26 | 13 | 2 |
| Rottweiler | 3 | 20 177 | 61 | 39 | 30 | 8 | 1 |
| Bulldog | 4 | 497 | 62 | 37 | 25 | 10 | 1 |
| Fila Brasileiro | 5 | 220 | 68 | 32 | 19 | 10 | 3 |
| Boerboel | 6 | 246 | 70 | 30 | 17 | 8 | 5 |
| Black Russian terrier | 7 | 767 | 72 | 27 | 19 | 7 | 1 |
| Bernese mountain dog | 8 | 17 869 | 73 | 27 | 18 | 7 | 3 |
| Otterhound | 9 | 137 | 73 | 27 | 22 | 4 | 1 |
| Chinese shar‐pei | 10 | 852 | 74 | 25 | 14 | 9 | 3 |
| Newfoundland | 11 | 8394 | 76 | 24 | 15 | 5 | 3 |
A primary objective of a registry is to provide a resource for breeders seeking health information on potential sires or dams. Another objective is to enable prospective owners to research the health of a breed in general or the parents and their relatives of a particular companion pet being considered. For example, Table 3.7.2 presents the health information of a dog of interest. In this example, for each dog, its registration number, birth date, and sex are listed followed by any health tests recorded. This particular dog has passed all its health clearances, as have a majority of its relatives. Health registries have the greatest value with broad participation; vast amounts of data provide the necessary power to predict outcomes and analyze trends.
Table 3.7.2 Health information on a dog of interest along with that of its sire, dam, and half siblings
Source: Data from www.ofa.org.
| Dog of interest | Registration | Birthdate | Sex | Relation | Hipsa | Elbowb | Eyesc | Thyroidd |
|---|---|---|---|---|---|---|---|---|
| Larentia di Villa Roma | DN09589103 | Dec 16 2004 | F | Self | BT‐4753G27 | BT‐EL2046F27 | BT‐EYE316 | BT‐TH315/27 |
| Sire/Dam | ||||||||
| Neartic de la Grande Lande | DL75874001 | Mar 13 1997 | M | Sire | BT‐3264G32 | BT‐EL754M32 |
BT‐2233
|