Vaccines for Older Adults: Current Practices and Future Opportunities. Группа авторов
target="_blank" rel="nofollow" href="#ulink_828c8260-6951-586c-b8d6-6133d5831617">4Marcos-Perez D, Sanchez-Flores M, Maseda A, Lorenzo-Lopez L, Millan-Calenti JC, Gostner JM, Fuchs D, Pasaro E, Laffon B, Valdiglesias V: Frailty in older adults is associated with plasma concentrations of inflammatory mediators but not with lymphocyte subpopulations. Front Immunol 2018;9:1056.
5Tanaka T, Biancotto A, Moaddel R, Moore AZ, Gonzalez-Freire M, Aon MA, Candia J, Zhang P, Cheung F, Fantoni G, Consortium CHI, Semba RD, Ferrucci L: Plasma proteomic signature of age in healthy humans. Aging Cell 2018;17:e12799.
6Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G: Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000;908:244–254.
7Dalbeth N, Merriman TR, Stamp LK: Gout. Lancet 2016;388:2039–2052.
8Qian F, Guo X, Wang X, Yuan X, Chen S, Malawista SE, Bockenstedt LK, Allore HG, Montgomery RR: Reduced bioenergetics and Toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. Aging (Albany NY) 2014;6:131–139.
9Butcher SK, Chahal H, Nayak L, Sinclair A, Henriquez NV, Sapey E, O’Mahony D, Lord JM: Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leukoc Biol 2001;70:881–886.
10Braga PC, Sala MT, Dal Sasso M, Pecile A, Annoni G, Vergani C: Age-associated differences in neutrophil oxidative burst (chemiluminescence). Exp Gerontol 1998;33:477–484.
11Tortorella C, Piazzolla G, Spaccavento F, Vella F, Pace L, Antonaci S: Regulatory role of extracellular matrix proteins in neutrophil respiratory burst during aging. Mech Ageing Dev 2000;119:69–82.
12Rao KM: Age-related decline in ligand-induced actin polymerization in human leukocytes and platelets. J Gerontol 1986;41:561–566.
13Rao KM, Currie MS, Padmanabhan J, Cohen HJ: Age-related alterations in actin cytoskeleton and receptor expression in human leukocytes. J Gerontol 1992;47:B37–B44.
14Sapey E, Greenwood H, Walton G, Mann E, Love A, Aaronson N, Insall RH, Stockley RA, Lord JM: Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood 2014;123:239–248.
15Montgomery RR, Shaw AC: Paradoxical changes in innate immunity in aging: recent progress and new directions. J Leukoc Biol 2015;98:937–943.
16Jorch SK, Kubes P: An emerging role for neutrophil extracellular traps in noninfectious disease. Nat Med 2017;23:279–287.
17Schauer C, Janko C, Munoz LE, Zhao Y, Kienhofer D, Frey B, Lell M, Manger B, Rech J, Naschberger E, Holmdahl R, Krenn V, Harrer T, Jeremic I, Bilyy R, Schett G, Hoffmann M, Herrmann M: Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat Med 2014;20:511–517.
18Fadini GP, Menegazzo L, Rigato M, Scattolini V, Poncina N, Bruttocao A, Ciciliot S, Mammano F, Ciubotaru CD, Brocco E, Marescotti MC, Cappellari R, Arrigoni G, Millioni R, Vigili de Kreutzenberg S, Albiero M, Avogaro A: NETosis Delays Diabetic Wound Healing in Mice and Humans. Diabetes 2016;65:1061–1071.
19Xu F, Zhang C, Zou Z, Fan EKY, Chen L, Li Y, Billiar TR, Wilson MA, Shi X, Fan J: Aging-related Atg5 defect impairs neutrophil extracellular traps formation. Immunology 2017;151:417–432.
20Hazeldine J, Harris P, Chapple IL, Grant M, Greenwood H, Livesey A, Sapey E, Lord JM: Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. Aging Cell 2014;13:690–698.
21Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD: β-Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares. Cell Rep 2017;18:2077–2087.
22Ziegler-Heitbrock L: Blood Monocytes and Their Subsets: Established Features and Open Questions. Front Immunol 2015;6:423.
23van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R, Shaw AC: Age-associated defect in human TLR-1/2 function. J Immunol 2007;178:970–975.
24van Duin D, Allore HG, Mohanty S, Ginter S, Newman FK, Belshe RB, Medzhitov R, Shaw AC: Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis 2007;195:1590–1597.
25Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A: Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science 2016;352:463–466.
26Molony RD, Nguyen JT, Kong Y, Montgomery RR, Shaw AC, Iwasaki A: Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. Sci Signal 2017;10:eaan2392.
27Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, Bockenstedt L, Malawista S, Bucala R, Shaw AC, Fikrig E, Montgomery RR: Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 2012;11:104–110.
28Gabanyi I, Muller PA, Feighery L, Oliveira TY, Costa-Pinto FA, Mucida D: Neuro-immune interactions drive tissue programming in intestinal macrophages. Cell 2016;164:378–391.
29Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Deep Dixit V: Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature 2017;550:119–123.
30Pirzgalska RM, Seixas E, Seidman JS, Link VM, Sanchez NM, Mahu I, Mendes R, Gres V, Kubasova N, Morris I, Arus BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass CK, Domingos AI: Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine. Nat Med 2017;23:1309–1318.
31Kong