Musculoskeletal Disorders. Sean Gallagher
or repairing tendons and bones. Elastin is a fibrous protein typically present as discontinuous fibrils (Figure 3.2) or sheets and confers the properties of stretch and elastic recoil (Young & Heath, 2000).
General Subtypes: Structure and Function
In this section, we summarize the general features of connective tissues and their function (see Table 3.1).
Loose connective tissue
Loose connective tissues are the most abundant in the body. In this general type of connective tissue (often divided into adipose, areolar, and reticular), the fibers are loosely woven and there are many cells. It is located around nerves and blood vessels, among others, and is composed of thin and relatively few fibers (collagenous, elastic, and/or reticular) and cell types, all embedded in a semifluid ground substance (Figure 3.1a). There are large numbers of cells and cellular processes, including fibroblasts, often adipocytes, immune cells, blood vessel and lymph vasculature cells, and neuronal processes (nerves) (Figure 3.1b). Functionally, this tissue provides cushioning, support, elasticity, and immune functions.
Table 3.1 General Features of Connective Tissues
Characteristic | Description |
---|---|
General types | Loose (adipose, areolar, reticular); dense (e.g., tendon, cartilage, and bone); fascia (e.g., epimysium) |
Cells | Main cell types: Fibroblasts, adipocytes, resident macrophages, plasma cells |
Extracellular matrix (ECM) | Main composition: Polysaccharides, water, glycosaminoglycans (GAGs), proteoglycans, glycoproteinsAdditional components: Collagen I/III, elastin, depending on subtype |
Function | Envelops, separates tissues and cells, cushions, supports, immune function, and more |
Figure 3.1 Loose and adipose connective tissues. (a) Loose connective tissue stained with hematoxylin and eosin (H&E). Elastic fibers (EF) and fibroblasts (F) are indicated. (b) Arteries and nerve in loose connective tissue (CT); H&E stained. (c) Adipose tissue near muscle fibers surrounded by dense fibrotic tissue induced by repetitive strain injury; Masson’s Trichrome stained. (d) Adipocytes around skeletal muscle fibers; H&E stained.
Areolar tissue
This type of loose connective tissue is the most widely distributed and is present in the dermis, around blood vessels, and nerves. It contains at one time or another, nearly all of the cell types normally found in connective tissue, including fibroblasts, macrophages, plasma cells, mast cells, adipocytes, and a few white blood cells. Its loose, randomly arranged fibers include collagen, elastic, or reticular. The ground substance is semifluid or gelatinous and contains primarily hyaluronic acid, chondroitin sulfate, dermatan sulfate, or keratan sulfate.
Adipose tissue
Adipose tissue is primarily composed of adipocytes. It can be found in the subcutaneous layer of skin, the marrow of long bones, between muscles, and around nerves and joints (Figure 3.1c,d). It reduces heat loss through the skin and provides energy reserves, support, and protection.
Reticular tissue
This type of loose connective tissue contains a fine network of collagen III fibers, often termed reticular fibers. It is present around blood vessels and muscle, within bone marrow, and in basement membranes.
Dense collagenous connective tissues
Dense connective tissues contain either regularly or irregularly arranged collagen fibers and fewer intercellular substance and cells than found in loose connective tissues (Figure 3.2). Examples of dense irregular connective tissues include the dermis of skin, deep fascia, the periosteum of bone, the perichondrium of cartilage, and organ capsules. Examples of dense regular connective tissues include tendons, ligaments, aponeuroses (thin flat tendon bands that connect one muscle to another or to bone), cartilage, and bone. Each is discussed in further detail separately in subsequent sections. Elastic tissue has a preponderance of elastic fibers and constitutes the ligament flava of vertebrae and arterial walls, among others.
Figure 3.2 Dense irregular connective tissue in the dermis of the skin. (a) Masson’s Trichrome staining detects the dense amount of collagen fibers. (b) Verhoeff Gieson Elastin Staining is used to detect elastic fibers (EFs). The black‐stained EFs are surrounded by collagen fibers.
Fascia
Fascia is the term applied to the sheets or broad bands of fibrous connective tissue that (a) lies beneath the skin; (b) attaches, stabilizes, encloses, and separates muscle and tendons from each other; and (c) separates internal organs from each other. It is classified by layer (superficial, deep, visceral, or peritoneal fascia), function, or anatomical location. Superficial fascia is the subcutaneous layer of connective tissue that lies immediately deep to the skin. It serves as a storehouse of water and fat (which acts as insulation) and provides a pathway for nerves, vessels, and immune cells to travel between other tissues (Figure 3.1b). Deep fascia is a denser connective tissue that holds muscles and tendons together, fills spaces between tissues, and lines the body wall and extremities (e.g., the lower leg’s crural fascia). Functionally, deep fascia allows free movement of muscles and tendons, carries blood vessels and nerves, and sometimes provides an attachment for muscle (e.g., the palmaris brevis muscle of the hand).
There are several extensions of deep fascia around and into individual muscles and tendons (Figure 3.3). The epimysium is the deep fascial dense connective tissue wrapping around the entire muscles. Invaginations of the epimysium into a muscle are termed perimysium (a type of irregular connective tissue) and endomysium (a type of reticular connective tissue). The epimysium, perimysium, and endomysium are all continuous with similar structures in tendons (epitenon, peritenon, and endotenon). Since tendons and aponeuroses (broad flat tendons) attach skeletal muscles to bones and other muscles, respectively, the continuity of these coverings allows skeletal muscles to produce movement.