Bacterial Pathogenesis. Brenda A. Wilson
as allergies and IBD. One current hypothesis is that helminths, and possibly protozoa as well, stimulate the arm of the immune system that consists of IgE, eosinophils, mast cells, and other cell types that are negatively associated with allergies and IBD. Support for this hypothesis arises from the fact that early stimulation of the gastrointestinal immune system by eukaryotic microbes allows this part of the immune response to develop normally. Conversely, failure to experience this type of stimulation may, in some people, predispose them to disease caused by overstimulation of the inflammatory response. The impact of the loss of these eukaryotic microbes on the bacterial microbiota has not yet been explored thoroughly, but efforts are now moving in this direction.
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