Methodologies in Amine Synthesis. Группа авторов

Methodologies in Amine Synthesis - Группа авторов


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200 regenerates 197 and meanwhile gives benzylic radical 201. The subsequent oxidation of 201 generates benzylic cation 202, which further reacts with 197 to deliver the desired amination product 198. The results of control experiments and some experimental observations add credit to this putative mechanism. For example, the existence of N‐centered radical intermediate 200 is suggested by the formation of its dimeric product, while benzylic radical 201 is captured by TEMPO in a radical trapping experiment. To demonstrate the intermediacy of benzylic cation 202, the authors performed the model reaction using a mixture of MeCN/AcOH (9 : 1) as the solvent, which provides the desired 198 in diminished yield, along with the by‐product benzyl acetate in 10% yield.

Chemical reaction depicts the visible-light-enabled direct benzylic C(sp3)–H amination.

      Source: Modified from Pandey and Laha [48].

Chemical reaction depicts the Benzylic C–H amination via visible-light photoredox catalysis.

      Source: Modified from Pandey et al. [49].

      3.3.3.2 N‐α‐C(sp3)—H Bond Amination

Chemical reaction depicts the electrochemical dehydrogenative imidation of N-methyl-substituted benzylamines.

      Source: Modified from Lian et al. [50].

Chemical reaction depicts the electrochemical dehydrogenative imidation of N-methyl substituted anilines.

      Source: Modified from Wang et al. [51].


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