Chemistry and Biology of Non-canonical Nucleic Acids. Naoki Sugimoto
9.4 G4 Helicases in Gene Expressions 9.5 G4 Helicases in Replication 9.6 G4 Helicases in Telomere Maintenance 9.7 Relation to Diseases by Loss of G4 Helicases 9.8 Insight into Specific Properties of Activities of G4 Helicase Under Cellular Conditions 9.9 Conclusion References
14 10 Dynamic Regulation of Biosystems by Nucleic Acids with Non-canonical Structures 10.1 Introduction 10.2 Time Scale of Biological Reactions 10.3 Processes in the Central Dogma Affected by Dynamics of Nucleic Acid Structures 10.4 Conclusion References
15 11 Cancer and Nucleic Acid Structures 11.1 Introduction 11.2 Detail Mechanism of Cancer 11.3 Non-canonical Structures of Nucleic Acids in Cancer Cells 11.4 Roles of Non-canonical Structures of Nucleic Acids in Cancer Cells 11.5 Conclusion References
16 12 Neurodegenerative Diseases and Nucleic Acid Structures 12.1 Introduction 12.2 Protein Aggregation-Induced Neurodegenerative Diseases 12.3 DNA Shows Key Role for Neurodegenerative Diseases 12.4 RNA Toxic Plays a Key Role for Neurological Diseases 12.5 Conclusion References
17 13 Therapeutic Applications 13.1 Introduction 13.2 Oligonucleotide Therapeutics 13.3 Non-canonical Nucleic Acid Structures as Therapeutic Targets 13.4 Non-canonical Nucleic Acid Materials for Inducing Non-canonical Structures 13.5 Conclusion References
18 14 Materials Science and Nanotechnology of Nucleic Acids 14.1 Introduction 14.2 Non-canonical Structure-Based Nanomaterials Resembling Protein Functions 14.3 Protein Engineering Using G4-Binding Protein 14.4 Regulation of Gene Expression by G4-Inducing Materials 14.5 Environmental Sensing 14.6 Conclusion References
19 15 Future Outlook for Chemistry and Biology of Non-canonical Nucleic Acids 15.1 Introduction 15.2 Exploring Potential: Properties of Non-canonical Structures in Unusual Media 15.3 Systemizing Properties: Prediction of the Formation of Non-canonical Nucleic Acids Structures 15.4 Advancing Technology: Applications of Non-canonical Structures Taking Concurrent Reactions into Account 15.5 Conclusion References
20 Index
List of Tables
1 Chapter 2Table 2.1 Thermodynamic parameters for duplex formations in 1M NaCl by DNA ol...Table 2.2 Free energy increments for tandem mismatches in RNA oligonucleotide...
2 Chapter 4Table 4.1 Hydration of G4 structures and duplexes.Table 4.2 Effects of molecular crowding reagents on stability and topology of...
3 Chapter 5Table 5.1 Human telomeric G4 structures available in the Protein Data Bank.
4 Chapter 6Table 6.1 Transcription process perturbs by non-canonical DNA.
5 Chapter 9Table 9.1 Helicases related to G4 unwinding.Table 9.2 Helicase related to human diseases.
6 Chapter 11Table 11.1 DNA and RNA G-quadruplexes related with cancer activation.
7 Chapter 12Table 12.1 Repeat expansion-related neurodegenerative disease.
8 Chapter 13Table 13.1 Oligonucleotide therapeutics approved in market.
9 Chapter 14Table 14.1 Representative list of DNA and RNA aptamers containing G4-forming ...Table 14.2 G4 structures located within mRNA 5′ untranslated regions shown ex...
10 Chapter 15Table 15.1 Studies of structures and stability of nucleic acids in ionic liqu...
List of Illustrations
1 Chapter 1Figure 1.1 The diffraction pattern of the canonical DNA duplex and its chemi...Figure 1.2 Chemical structures of base pairs via Watson–Crick or Hoogsteen t...